After the gut, the second largest and most diverse microbiome in the body is located in the mouth. The oral microbiome is becoming an increasing area of interest in the medical community as research highlights several connections between chronic oral dysbiosis and systemic diseases, with inflammation being a common link. Pathogenic oral bacteria may influence inflammatory pathways particularly via the gut and by translocation through perivascular spaces. Thus, maintaining balance is the oral microbiome is a critical strategy for reducing inflammatory burden and reducing the risk of certain diseases. On this episode of Pathways to Well-Being, we welcome 2023 Annual International Conference speaker Doug Thompson, DDS, FAAMM, ABAAHP, to discuss new prevention and treatment opportunities that bridge the gap between dental care and health care.