TCR signatures as biomarkers of autoimmune diseases

AIRR Community FOCiS 2021 Symposium
TCR signatures as biomarkers of autoimmune diseases
Encarnita Mariotti-Ferrandiz, Sorbonne Université, France

Abstract: With the advances in next-generation sequencing and data modelling, T-cell receptor repertoire is now believed to provide biomarkers of diagnostics. In the race of methods and tools development, it is important to ensure the reliability of such complex biological components characterized by an uneven diversity. After introducing our recent comparative study that evaluated the performances of various molecular biology methods commonly used in the field, I will introduce our method and results of TCR signatures identification in several autoimmune diseases.

Speaker Bio: Dr. Encarnita Mariotti-Ferrandiz is an Associate Professor for Systems Immunology at Sorbonne Universite (Paris, France). Her group, part of the i3 laboratory, studies T-cell repertoires in physiological and
pathological contexts, from sample to data modelling. The main objectives being to (i) better understand T-cell selection and tissue homing and (ii) to identify biomarkers of disease status.

Dr. Mariotti-Ferrandiz is the former Co-lead and still member of the AIRR-C Biological Resources Working Group, a member of the AIRR-C Executive Sub-committee, the AIRR-C Meetings Sub-committee and the AIRR-C Diagnostics Working Group.