Study finds B-cells can help predict HER2-positive breast cancer treatment response

#breastcancer #blymphocytes #cancermedication #cancerresearch #clinicaltrials #biomarkers #cancerimmunology #rnasequencing

Researchers have found that measuring activation of immune-system B cells may be better than measuring either T-cell activation or the total number of immune cells in and around a tumor, called tumor-infiltrating lymphocytes (TILs), in predicting whether HER2-positive breast cancer responds to treatment.

In HER2-positive breast cancer, the immune system is key to the effectiveness of response to anti-HER2 drugs. Important cells in the body’s immune system include B-cells, which create antibodies that neutralize cancer cells and infections as well as T-cells, which directly fight cancers and infections.

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