p53 mutation contributes to the development of atherosclerotic cardiovascular disease: Study

#cardiovasculardisease #atherosclerosis #bloodcells #riskassessment #animalresearch #cellularregulation #cellresponses #progenitorcells

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), working in collaboration with institutes in the USA, has demonstrated that acquired mutations in the gene encoding the protein p53 contribute to the development of atherosclerotic cardiovascular disease.

Known as the Guardian of the Genome, p53 helps to maintain the integrity of the hereditary material inside cells by regulating multiple cell functions in response to cellular stresses.The presence of acquired p53 gene mutations in blood cells increases the risk of developing various types of cancer, including blood cancers.

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