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Nitrofurantoin tablets ip 100mg in hindi | Uribid 100 mg | Treatment of Urinary tract infection



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Nitrofurantoin tablets ip 100mg in hindi | Uribid 100 mg | Treatment of Urinary tract infection
In this video you'll know about Nitrofurantoin which is a primarily bacteriostatic compound,
but may be cidal at higher concentrations.
In acid urine its activity is enhanced at lower pH.
It inhibits many gram negative bacteria, but
due to development of resistance, activity is now restricted largely to E.coli.
It antagonizes the action of nalidixic acid.

Indications:
Urinary tract infection
Cystitis
pyelitis & pyelo-nephritis
post-operative infections of urinary tract.

Dosage 50-100 mg 6 hrly with meals. Children: 6 mg/kg bodywt daily in 4 divided doses.

Contra-indications:
Impaired renal function
Urine turns dark brown on exposure to air.
Liver damage & a pulmonary reaction Concomitant use of Probenecid & Nalidixic acid.
Acidify urine
Paediatrics: Contraindicated in under 1 year.
Pregnancy: Safety not established.
Lactation: Use with caution. May cause anaemia in G6PD deficient infants.
Elderly: No special problem.

Side-effects:
G.I. intolerance
nausea
diarrhoea
Chills fever & leucopenia
Peripheral neuritis & neurological effects.
Haemolytic anaemia.

Drug Interactions: Antagonise Nalidixic acid.
Absorbtion reduced by Magnesium trisilicate.
Probenecid reduces excretion
Urinary excretion of Pyridoxin increased.

Brands
#Niftas
#Uribid
#Niftran
#Nifty
#Urifast
#Nitrobest


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