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Nanoparticle Based Delivery of Gene Editing Enzymes



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Presented By: Niren Murthy, PhD

Speaker Biography: Dr. Niren Murthy is a professor in the Department of Bioengineering at the University of California at Berkeley. Dr. Murthy’s scientific career has focused on the molecular design and synthesis of new materials for drug delivery and molecular imaging. The Murthy laboratory has been recently focused on developing non-viral delivery vehicles that can deliver Cas9 protein, gRNA and Donor DNA in vivo.

Webinar: Nanoparticle Based Delivery of Gene Editing Enzymes

Webinar Abstract: Cas9 based therapeutics have the potential to revolutionize the treatment of genetic diseases. However, safe and effective methods for delivering Cas9 protein, gRNA and donor DNA need to be developed before the therapeutic potential of CRISPR based therapeutics can be realized. In this presentation, I will describe a non-viral Cas9 delivery vehicle, termed CRISPR-Gold, which can induce homology directed DNA repair (HDR) in vivo by directly delivering Cas9 protein, gRNA, and donor DNA. CRISPR-Gold is composed of gold nanoparticles assembled with the Cas9/gRNA ribonucleoprotein (RNP) complex, donor DNA, and an endosomal disruptive polymer.

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1. Make sure you’re a registered member of LabRoots https://www.labroots.com/virtual-event/crispr-2021/agenda
2. Watch the webinar on YouTube or on the LabRoots Website https://www.labroots.com/webinar/nanoparticle-based-delivery-gene-editing-enzymes
3. Click Here to get your PACE credits (Expiration date – September 29, 2023): https://www.labroots.com/credit/pace-credits/6681/third-party

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