Marburg virus disease (MVD), Signs and Symptoms, Diagnosis, Treatment, Physiology Made Easy

▪ Marburg virus that cause marburg virus disease (MDV) also known as marburg hemorrhagic fever is a zoonotic virus that is initially transmitted from animals to humans. The animal reservoir in nature for the Marburg virus is the African fruit bats. Marburg virus is clinically similar to the ebola virus and can lead to Marburg virus disease, formerly known as Marburg hemorrhagic fever.
▪ Signs and symptoms of Marburg virus infection typically appear 2-21 days after exposure to the virus. Early signs and symptoms of marburg virus disease (MVD) typically consist of fever, chills, headache, sore throat, weakness, and muscle aches. As it progresses, diarrhea, abdominal pain, nausea, vomiting, rash, and severe hemorrhagic signs and symptoms may also occur. In severe cases, confusion, seizures, shock, multiple organ failure, and death may follow.
▪ Marburg virus disease (MVD) may be diagnosed using throat and nasal swabs, cerebrospinal fluid samples, urine samples, and/or blood samples. ELISA testing, RT-PCR, IgM and/or IgG capture ELISA, and virus isolation by cell culture may also be used in diagnostic measures.
▪ Treatment of Marburg virus infection is limited to supportive care, typically after hospitalization, which includes rest, hydration, oxygen, and treatment of specific symptoms upon onset. Intravenous and/or oral fluids may be provided to replace lost fluids, stabilize electrolytes, and maintain blood pressure. Blood transfusions may also be provided to replace lost blood and clotting factors.
▪ While there are not currently any approved drug treatments for Marburg virus infection, immunotherapeutic treatments known as monoclonal antibody therapies are currently under development and evaluation for treatment of MVD. Antiviral therapies, such as remdesivier and favipiravir, have been used in clinical studies for Ebola that may also be tested for use in MVD.
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Chapters:
0:00 - Marburg Virus Disease (MVD)
0:46 - Marburg Virus Replication
0:58 - Marburg Virus Disease (MVD) Symptoms
2:03 - Marburg Virus Disease (MVD) Diagnosis
2:39 - Marburg Virus Disease (MVD) Treatment

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