Mapping Endometriosis: A Vast Cellular Atlas Is Created | Cedars-Sinai



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Investigators at Cedars-Sinai have created a unique and detailed molecular profile of endometriosis to help improve therapeutic options for the millions of women suffering from the disease.

The study is published today in the journal Nature Genetics: https://www.nature.com/articles/s41588-022-01254-1

“Endometriosis has been an understudied disease in part because of limited cellular data that has hindered the development of effective treatments. In this study we applied a new technology called single-cell genomics, which allowed us to profile the many different cell types contributing to the disease,” said Kate Lawrenson, PhD, an associate professor in the Department of Obstetrics and Gynecology at Cedars-Sinai, and co-senior and corresponding author of the study.

Endometriosis is a condition in which cells of the uterine lining, or ones similar to endometrial tissue, are found growing in the wrong places, most commonly on the ovaries, fallopian tubes and in the abdominal cavity. The disease impacts about 10%
of women, usually during their reproductive years. Patients with the disorder can experience chronic pain, infertility, headaches, fatigue, and bowel and bladder dysfunction.

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00:00 What is endometriosis?
00:40 What are the challenges in studying endometriosis?
00:59 What does the latest research show?
01:28 What is the cell atlas and how will it help women?
01:54 Where does endometriosis research go from here?
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