Getting Some Gastric Juices Flowing

Disorders of stomach secretion were revolutionized at the discovery of proton pump inhibitor therapy. For example, treatment of peptic ulcer disease before 1989 sometimes would be surgery. On a less severe scale, heartburn sometimes happen spontaneously, but is there something we could just change without any other intervention if it appears often? Maybe. PPI's profoundly increase stomach acid levels, so evidence for limiting proton pump activity as a way to control stomach acid is plausible, but we likely cannot and should not completely eliminate dietary potassium intake. However limiting it for a time may be help.

References:
Role of potassium in acid secretion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622792/

Gastric acid level of humans must decrease in the future
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684463/

The impact of proton pump inhibitors on the human gastrointestinal microbiome. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254461

Diet and Gastroesophageal Reflux Disease https://www.asge.org/docs/default-source/about-asge/newsroom/doc-gerd_infographic_final.pdf

The effect and mechanism of action of capsaicin on gastric acid output.
https://pubmed.ncbi.nlm.nih.gov/19296048

The Physiology of the Gastric Parietal Cell. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327232/

Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase.
https://www.nature.com/articles/290159a0

Priming the (Proton) Pump. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844173/

A nonelectrogenic H+ pump in plasma membranes of hog stomach. https://www.jbc.org/article/S0021-9258(17)32907-1/pdf

#shorts #stomach #gas #candy