George Church, PhD: Rewriting Genomes to Eradicate Disease and Aging

George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.

Show notes and transcript:
Dr. George Church on Twitter:
Dr. George Church on Instagram:
Church lab:
Regenesis Book:

Apple Podcasts:

00:00:00 Intro
00:02:52 History of the Human Genome Project
00:09:48 Manufacturing cell phones (with biology)
00:13:21 Genome Project-Write
00:15:51 Writing a human Y chromosome (from scratch)
00:16:36 What if you could eliminate viral disease?
00:18:38 De-extinction and reinstating lost traits and genes
00:22:53 The Vertebrate Genomes Project
00:25:35 AlphaFold and other AI tools
00:37:14 CRISPR vs. Base Editing (emerging tools of genetic engineering)
00:45:27 Why multiplex editing will change the world
00:48:05 Molecular flight recorder
00:49:18 Preventing viral spillover and enhancing livestock
00:53:27 PCSK9 gene therapy for cholesterol
00:56:17 Is aging an evolved program?
01:01:08 Treating aging with a combination gene treatment
01:04:51 Does animal research help us understand human aging?
01:07:28 Organoids as a model and therapeutic
01:09:21 Could engineered transplant organs become better than the originals?
01:12:05 Embryo editing controversy
01:24:28 Gene editing for space travel
01:26:28 Can synthetic biology alleviate poverty?
01:29:55 Is in vitro fertilization and embryo selection practically similar to editing?
01:35:00 The occasional cost of brilliance and neurodivergence
01:41:33 Eradicating disease with Gene Drive
01:44:43 Technologies to solve Lyme disease
01:47:45 Personal experience with narcolepsy and creativity
01:56:29 Why George encoded his book in DNA


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