Featured

Genetic mapping identifies heart disease risk in people with type 2 diabetes



Published
#Genemap #mayidentify #heartdisease
CC0 Public Domain

Risk scores based on genetic profiles predict the likelihood that high blood pressure will lead to heart disease or stroke in people with type 2 diabetes, according to a study published today in the American Heart Association peer-reviewed journal Hypertension. The tool is particularly useful in guiding the management of patients newly diagnosed with type 2 diabetes or prediabetes.

Previous research has confirmed that adults with type 2 diabetes are twice as likely to have a heart attack or stroke than those without type 2 diabetes. Various health indicators, such as blood pressure, cholesterol and blood sugar levels, are often used to determine a person's risk of heart disease. In the study, researchers looked at whether genetic variants associated with high blood pressure in people with type 2 diabetes were also associated with later heart disease or stroke, and used this information to determine a risk score.

"The increased genetic risk of high blood pressure may make some people with type 2 diabetes more likely to develop heart disease, stroke, or cardiovascular disease," said study lead author Pankaj Arora, MD, director of the Cardiac Genomics Clinical Program and Cardiology. Clinical and Translational Research Program at the University of Alabama at Birmingham. "We conducted this study to determine whether this genetic risk score could identify patients with type 2 diabetes at higher risk of cardiovascular events, and whether strict glycemic control could reduce the association between genetic risk of hypertension and cardiovascular outcomes. Contact." Impact. "

Arora and colleagues reviewed the medical records of 6,335 participants in the Action for Cardiovascular Risk Control in Diabetes (ACCORD) study database for which genetic data was available. The study group was 37 percent female, and participants self-identified as their race or ethnicity: 15 percent were African American, 6 percent Hispanic; 70 percent were white; and 9 percent selected the "Other" category. All participants had type 2 diabetes and hypertension and were followed for 3.5 years.

The genetic variation maps of more than 1,000 common genetic variants known to affect blood pressure were compared to the study participants' DNA to determine the participants' genetic risk. More matches between the participants' DNA and profiles of known blood pressure gene variants corresponded to higher genetic risk scores.

Genetic risk score identifies study participants, researchers find
Category
Health
Be the first to comment