Computational Modeling of DNA Communication in the Nucleus



Published
http://www.iBiology.org

What do chromosomes look like in our #cells? In this 2022 Share Your Research Talk, Wang describes his #research to build a mathematical model for a process called Loop Extrusion, which describes how DNA folds and forms loops at kilobase scale. This model helps us understand complex interactions between DNA fragments as well as their 3D structure . The model can be used to predict how small changes in DNA sequence disrupt higher-order chromatin architecture and have implications for common genetic diseases like cancer and Alzheimer’s disease.

Speaker Biography: Wang Xi, Ph.D. completed his doctoral program at Johns Hopkins University. At the time of filming, Wang was a Ph.D. candidate and his thesis research focused on chromatin interactions and their implications on gene regulation through computational modeling.



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Health
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