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Complex Diseases? Blame it on the fibroblasts | Cups&Cakes Webinar Series



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Mesenchymal cells (MCs) refer to a variety of cell types, most commonly tissue fibroblasts and mesenchymal stromal cells, which form tissue microenvironments, mediate tissue structure and function and regulate immune responses. In the past decade, our lab contributed to the understanding of the causal role played by tissue fibroblasts in immunity, inflammation and cancer. Understanding the cellular heterogeneity and the physiological significance of fibroblasts in the pathophysiology of chronic inflammatory disease and cancer remains a great challenge that promises to introduce novel concepts and therapies for these complex diseases.

Meet the speaker

George Kollias is a Member of the Academy of Athens, Professor and Director of the Department of Physiology (Medical School, UoA), and Associated Researcher at the Biomedical Sciences Research Center "Alexander Fleming" in which he served as President and Director (2002-2010 and 2017-2020). He has pioneered genetic approaches to study the function of cytokine signalling in animal models of human diseases such as chronic inflammation, autoimmunity and cancer. His lab provided proof of principle preclinical studies that led to the development of anti-TNF therapies for Rheumatoid Arthritis. In 2014 he was awarded an Advanced ERC Grant to study the role of mesenchymal cells in intestinal epithelial and immunological homeostasis.

About the Cup&Cakes webinar series

The Cups&Cakes meetings seek to create a discussion forum for CIVIS researchers to connect and get an overview of what is happening in other partner universities on a specific topic. In the longer term, these exchanges also aim to foster exchanges and develop potential collaborations within the CIVIS Alliance.
Category
Health
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