Biofluid-based biomarkers for neurological disease

Presented By:
Steffen Halbgebauer, PhD
Dr. Hayrettin Tumani
Yoav Noam, PhD

Speaker Biography:
Steffen Halbgebauer is a postdoctoral researcher in the Department of Neurology at Ulm University Hospital Germany. He obtained a PhD in molecular medicine in 2017 and since then works as a neurological researcher. His main interest are wet biomarkers for neurodegenerative and neuroinflammatory diseases. He works on the identification and validation of novel markers for the early diagnosis and prediction of neurological diseases. Steffens research also focuses on the establishment of novel immunoassays for biomarker candidates which can be used for patient stratification and as objective readouts in therapeutic trials.
Hayrettin Tumani was trained at the Medical School of the University of Göttingen from 1984-1990 and "Neuroscience" at the University of California San Diego from 1987-1988. He received his doctoral degree in medicine from the University of Göttingen in 1992. Prof. Tumani is head of the Multiple Sclerosis Outpatient Unit and of the Clinical Trials Centre for Multiple Sclerosis as well as Head of the Laboratory for CSF analysis at the Neurology Department of the University Hospital Ulm since 1999. He has contributed to more than 330 original papers, overviews or case reports listed in pubmed, and to over 40 book chapters and to 6 book editions on the topics of CSF analysis in neuro-psychiatric diseases, as well as on the pathogenesis, diagnosis and therapy of neuroinflammatory and neurodegenerative diseases.
Yoav Noam is a manager for the Simple Plex Development group at Bio Techne. He holds a PhD degree in molecular and cellular neurobiology from the University of Amsterdam and has obtained his postdoctoral training at the University of California-Irvine and at Yale University. Yoav and his team currently work to further expand the capabilities of the Simple Plex/ Ella automated platform. Their mission is to provide robust and easy-to-implement solutions for the biomarker research community across disciplines, including Neuroscience, Immuno-oncology, and Cell and Gene Therapy.

Webinar:
Biofluid-based biomarkers for neurological disease

Webinar Abstract:
Biofluid-based neurological biomarkers have shown promise in helping to improve diagnostic accuracy, predict disease progression, and evaluate responses to therapeutic interventions. Neurofilament light- and heavy-chain (NFL, NFH) are cytoskeletal neuronal proteins that are well-suited as biomarkers for neurodegeneration; while basal levels of neurofilaments circulate in both CSF and blood, neurofilament concentrations can rise substantially upon neuronal injury. Because basal NFL levels in serum and plasma are typically in the low picogram per milliliter, sensitive, robust, and reproducible assays are needed to provide high-quality data for monitoring neurodegenerative disease progression and treatment.
In this presentation, attendees will learn how a highly sensitive, automated assay workflow can provide robust, high-quality results on low abundance biomarkers in serum, plasma, and CSF. The discussion will highlight examples of NFL and NFH biomarker profiling related to neurological diseases. Presenters will demonstrate how using, among others highly sensitive, reproducible Simple Plex™ assays provide precise biomarker measurements even at the low levels detected in serum and plasma.

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