Autoimmune hemolytic anemia type cold (cold agglutinin disease)

Cold agglutinin disease is a rare form of autoimmune hemolytic anemia caused by cold-reacting autoantibodies. Autoantibodies that bind to the erythrocyte membrane leading to premature erythrocyte destruction (hemolysis) characterize autoimmune hemolytic anemia.
Peripheral blood smears may reveal clumps of red blood cells (RBCs).