Augmenting neurogenesis rescues the engram in Alzheimer's disease

Augmenting Neurogenesis Rescues Memory Impairments in Alzheimer's disease by Restoring the Memory Stowing Neurons

Original paper: https://rupress.org/jem/article/219/9/e20220391/213413/Augmenting-neurogenesis-rescues-memory-impairments

Video Summary by Rachana Mishra (The University of Illinois at Chicago)

Deficits in hippocampal neurogenesis cause cognitive impairments in Alzheimer's disease by compromising the memory storage. Augmenting neurogenesis rescues memory by recruiting more new neurons with restored spine density and transcription profile. AD- linked genes regulate the memory stowing neurons.

Keywords: Alzheimer's disease, adult hippocampal neurogenesis, engram, learning and memory, APP, ApoE