Accelerating drug discovery to help people with brain diseases

We are an open science platform that promotes the sharing of scientific research to accelerate the discovery of new treatments for neurological disorders benefiting patients worldwide. At the EDDU we apply the technology of induced pluripotent stem cells (iPSCs) to study brain disorders directly in patients cells. Our work contributes to the acceleration of drug discovery by providing training to other scientists, through collaborations with academic and industry partners, and through sharing data and materials.
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Mohamed NV, Sirois J, Ramamurthy J, Mathur M, Lépine P, Deneault E, Maussion G, Nicouleau M, Chen CX, Abdian N, Soubannier V, Cai E, Nami H, Thomas RA, Wen D, Tabatabaei M, Beitel LK, Singh Dolt K, Karamchandani J, Stratton JA, Kunath T, Fon EA, Durcan TM. Midbrain organoids with an gene triplication model key features of synucleinopathy. Brain Commun. 2021 Sep 25;3(4):fcab223. doi: 10.1093/braincomms/fcab223. PMID: 34632384; PMCID: PMC8495137.

Deneault E, Chaineau M, Nicouleau M, Castellanos Montiel MJ, Franco Flores AK, Haghi G, Chen CX, Abdian N, Shlaifer I, Beitel LK, Durcan TM. A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis. Methods. 2021 Sep 6:S1046-2023(21)00208-5. doi: 10.1016/j.ymeth.2021.09.002. Epub ahead of print. PMID: 34500068.

Mohamed NV, Lépine P, Lacalle-Aurioles M, Sirois J, Mathur M, Reintsch W,
Beitel LK, Fon EA, Durcan TM. Microfabricated disk technology: Rapid scale up in midbrain organoid generation. Methods. 2021 Jul 24:S1046-2023(21)00195-X. doi: 10.1016/j.ymeth.2021.07.008. Epub ahead of print. PMID: 34314827.

Chen CX, Abdian N, Maussion G, Thomas RA, Demirova I, Cai E, Tabatabaei M, Beitel LK, Karamchandani J, Fon EA, Durcan TM. A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types. Methods Protoc. 2021 Jul 19;4(3):50. doi: 0.3390/mps4030050. PMID: 34287353; PMCID: PMC8293472.

Jin JW, Fan X, Del Cid-Pellitero E, Liu XX, Zhou L, Dai C, Gibbs E, He W, Li
H, Wu X, Hill A, Leavitt BR, Cashman N, Liu L, Lu J, Durcan TM, Dong Z, Fon EA, Wang YT. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Commun Biol. 2021 Feb 19;4(1):232. doi: 10.1038/s42003-021-01746-6. PMID: 33608634; PMCID: PMC7895943.

Thiry L, Hamel R, Pluchino S, Durcan T, Stifani S. Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing. Neuroscience. 2020 Dec 1;450:57-70. doi: 10.1016/j.neuroscience.2020.04.041. Epub 2020 May 5.
PMID: 32380268.

Castellanos-Montiel MJ, Chaineau M, Durcan TM. The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS. Front Cell Neurosci. 2020 Nov 13;14:594975. doi: 10.3389/fncel.2020.594975. PMID: 33281562; PMCID: PMC7691654.

Zhang I, Lépine P, Han C, Lacalle-Aurioles M, Chen CX, Haag R, Durcan TM,
Maysinger D. Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures. Cells. 2020 Nov 7;9(11):2434. doi: 10.3390/cells9112434. PMID: 33171886; PMCID: PMC7695149.

Siddu A, David LS, Lauinger N, Chen X, Saint-Pierre M, Alpaugh M, Durcan T, Cicchetti F. Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication. Neurobiol Dis. 2020 Nov;145:105042. doi: 10.1016/j.nbd.2020.105042. Epub 2020 Aug 13. PMID: 32798729.

Soubannier V, Maussion G, Chaineau M, Sigutova V, Rouleau G, Durcan TM,
Stifani S. Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery. Neurosci Lett. 2020 Jul 13;731:135028. doi: 10.1016/j.neulet.2020.135028. Epub 2020 May 4. PMID: 32380146.
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